
{"id":789,"date":"2019-08-19T19:08:50","date_gmt":"2019-08-19T19:08:50","guid":{"rendered":"http:\/\/labs.la.utexas.edu\/tucker-drob\/?page_id=789"},"modified":"2025-04-25T21:19:37","modified_gmt":"2025-04-25T21:19:37","slug":"genomic-sem","status":"publish","type":"page","link":"https:\/\/labs.la.utexas.edu\/tucker-drob\/genomic-sem\/","title":{"rendered":"Genomic SEM"},"content":{"rendered":"\n<p>Genomic Structural Equation Modelling (Genomic SEM) is a flexible statistical framework method for modeling the joint genetic architecture of constellations of genetically correlated traits and incorporating genetic covariance structure into multivariate GWAS discovery. Genomic SEM is applied to conventional GWAS summary statistics for the individual phenotypes of interest.&nbsp;It does not require raw data.<\/p>\n\n\n\n<p>To get started using the GenomicSEM R package, follow this link:&nbsp;<a href=\"https:\/\/github.com\/MichelNivard\/GenomicSEM\/wiki\" target=\"_blank\" rel=\"noopener noreferrer\">GenomicSEM wiki<\/a><\/p>\n\n\n\n<p>To read the paper introducing Genomic SEM, follow these links: <a href=\"http:\/\/rdcu.be\/bvn7t\" target=\"_blank\" rel=\"noopener noreferrer\">Paper<\/a>&nbsp;<a href=\"http:\/\/labs.la.utexas.edu\/tucker-drob\/files\/2019\/05\/Genomic-SEM-Supplement.pdf\">Supplement(Text\/Figures)<\/a>&nbsp;<a href=\"http:\/\/labs.la.utexas.edu\/tucker-drob\/files\/2020\/01\/41562_2019_566_MOESM3_ESM-1.xlsx\">Supplement(Tables)<\/a><\/p>\n\n\n\n<p>A video overview of Genomic SEM can be found here: <a href=\"https:\/\/www.youtube.com\/watch?v=ECwQS5UD3YM\" target=\"_blank\" rel=\"noopener noreferrer\">PGC Worldwide Lab Meeting <\/a><\/p>\n\n\n\n<p>Subscribe to the Genomic SEM Users Google group <a href=\"https:\/\/groups.google.com\/forum\/#!forum\/genomic-sem-users\">here<\/a>.<\/p>\n\n\n\n<p>The full citation for the paper introducing Genomic SEM is:<\/p>\n\n\n\n<p>Grotzinger, A. D., Rhemtulla, M., de Vlaming, R., Ritchie, S. J., Mallard, T. T.,&nbsp; Hill, W. D, Ip, H. F., Marioni, R. E., McIntosh, A. M., Deary, I. J., Koellinger, P. D., Harden, K. P., Nivard, M. G., &amp; Tucker-Drob, E. M. (2019). Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits.<em>&nbsp;Nature Human Behaviour,<\/em>&nbsp;<em>3,&nbsp;<\/em>513-525.&nbsp;[Nivard &amp; Tucker-Drob jointly directed this work]<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"\/\/labs.la.utexas.edu\/tucker-drob\/files\/2020\/05\/DgTaqEEUYAYClT-.jpeg\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/\/labs.la.utexas.edu\/tucker-drob\/files\/2020\/05\/DgTaqEEUYAYClT--1024x768.jpeg\" alt=\"\" class=\"wp-image-894\" srcset=\"https:\/\/labs.la.utexas.edu\/tucker-drob\/files\/2020\/05\/DgTaqEEUYAYClT--1024x768.jpeg 1024w, https:\/\/labs.la.utexas.edu\/tucker-drob\/files\/2020\/05\/DgTaqEEUYAYClT--768x576.jpeg 768w, https:\/\/labs.la.utexas.edu\/tucker-drob\/files\/2020\/05\/DgTaqEEUYAYClT--1536x1152.jpeg 1536w, https:\/\/labs.la.utexas.edu\/tucker-drob\/files\/2020\/05\/DgTaqEEUYAYClT-.jpeg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genomic Structural Equation Modelling (Genomic SEM) is a flexible statistical framework method for modeling the joint genetic architecture of constellations of genetically correlated traits and incorporating genetic covariance structure into multivariate GWAS discovery. Genomic SEM is applied to conventional GWAS summary statistics for the individual phenotypes of interest.&nbsp;It does not require raw data. To get [&hellip;]<\/p>\n","protected":false},"author":72,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-789","page","type-page","status-publish","hentry","entry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"site-graphic":false},"uagb_author_info":{"display_name":"et5793","author_link":"https:\/\/labs.la.utexas.edu\/tucker-drob\/author\/et5793\/"},"uagb_comment_info":0,"uagb_excerpt":"Genomic Structural Equation Modelling (Genomic SEM) is a flexible statistical framework method for modeling the joint genetic architecture of constellations of genetically correlated traits and incorporating genetic covariance structure into multivariate GWAS discovery. Genomic SEM is applied to conventional GWAS summary statistics for the individual phenotypes of interest.&nbsp;It does not require raw data. To get&hellip;","_links":{"self":[{"href":"https:\/\/labs.la.utexas.edu\/tucker-drob\/wp-json\/wp\/v2\/pages\/789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.la.utexas.edu\/tucker-drob\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.la.utexas.edu\/tucker-drob\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.la.utexas.edu\/tucker-drob\/wp-json\/wp\/v2\/users\/72"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.la.utexas.edu\/tucker-drob\/wp-json\/wp\/v2\/comments?post=789"}],"version-history":[{"count":9,"href":"https:\/\/labs.la.utexas.edu\/tucker-drob\/wp-json\/wp\/v2\/pages\/789\/revisions"}],"predecessor-version":[{"id":1424,"href":"https:\/\/labs.la.utexas.edu\/tucker-drob\/wp-json\/wp\/v2\/pages\/789\/revisions\/1424"}],"wp:attachment":[{"href":"https:\/\/labs.la.utexas.edu\/tucker-drob\/wp-json\/wp\/v2\/media?parent=789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}