Smoking Cessation Treatment

Approach Bias Retraining and Smoking Cessation

Study Title: Approach Bias Retraining to Augment Smoking Cessation

Sponsor: National Institute on Drug Abuse

Objective: The study examines the use of a computerized joystick task to augment the effects of standard smoking cessation counseling and nicotine replacement therapy. The joystick task training is designed to weaken automatic cigarette- approach and strengthen automatic cigarette avoidance. Eligible participants will receive free smoking counseling session once a week for seven weeks. In addition, participants will receive 8 weeks of Nicoderm CQ®, 24-hour transdermal nicotine patches (TNP). Participation in this study has the potential to help individuals quit smoking and, ultimately, provide unique information about the importance of targeting implicit processes to complement standard care. Participants will receive up to $250 in compensation by the completion of the study.

Clinical Trials Registry:
https://clinicaltrials.gov/ct2/show/NCT03325777?term=approach+bias+retraining&recrs=ab&rank=1

Status: This study is currently recruiting participants.

IRB Protocol: 2017-04-0006

Please click here for more information on how to become involved.

 YMCA Exercise Intervention for Smoking Cessation Study 

Study Title: CPRIT-YMCA Study

Sponsor: Cancer Prevention Research Institute of Texas (CPRIT)

Objective: The study examines the use of exercise to enhance the outcome of smoking cessation within smokers who are sensitive to stress and anxiety. Specifically, this study aims to evaluate the feasibility and effectiveness of a community-based personalized exercise-smoking cessation intervention.
Eligible participants will be paired with a personal trainer and undergo 15 weeks of exercise sessions at an Austin-area YMCA. In addition, participants will receive smoking cessation counseling through the Texas Tobacco Quitline. The study also provides 8 weeks of Nicoderm CQ®, 24-hour transdermal nicotine patches (TNP). Participation in this study will help investigators determine whether an exercise and smoking cessation program can be widely implemented in a community-based organization, such as the YMCA. Participants will receive up to $250 in compensation by the completion of the study

Clinical Trials Registry:
https://clinicaltrials.gov/ct2/show/NCT03080090?term=YMCA&rank=5

Status: This study is currently recruiting participants.

IRB Protocol: 2016-12-0049

Please click here for more information on how to become involved.

 

Panic and Smoking Cessation

Study Title: Enhancing Panic and Smoking Reduction Treatment with D-Cycloserine

Sponsor: National Institute on Drug Abuse

Objective: This study aims to evaluate whether d-cycloserine can enhance the outcome of a smoking cessation intervention designed for smokers who have experienced panic attacks. D-cycloserine targets receptors in the brain that are involved in learning and memory. Thus, d-cycloserine is not an antidepressant or anxiolytic medication, but rather an agent that aims to improve the memory of the learning that takes place during psychotherapy session. Eligible participants will receive 7 weeks of individual cognitive behavioral therapy (CBT), which will target both smoking cessation and elevated panic symptoms. In addition, participants will be randomly assigned to either 1) receive three 250-mg doses of d-cycloserine before sessions 3-5; or 2) receive three 250-mg doses of a placebo before sessions 3-5. The primary outcome measure is the smoking abstinence, which will be assessed at six separate visits following quit date (week 5). The patient’s participation will help investigators determine whether or not administering a dose of d-cycloserine before a therapy session will help the patient to retain the new behaviors learned in session and therefore, increase smoking abstinence rates. Participants will receive up to $200 in compensation by the completion of the study.

Clinical Trials Registryhttp://clinicaltrials.gov/ct2/show/NCT01944423?term=enhancing+panic&rank=1

Status: This study is currently recruiting participants.

IRB Protocol: 2013-09-0022

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PTSD and Smoking Treatment

Study Title: Integrated PTSD and Smoking Treatment

Sponsor: National Institute on Drug Abuse

Objective: Research shows that people with PTSD are more likely to smoke than people without PTSD. It also shows that people with PTSD have more difficulty at attempts to quit smoking. This study is part of a program aimed at finding out how best to help smokers quit who also have PTSD. One option is to give patients standard smoking cessation treatment including nicotine replacement and cognitive behavioral therapy. Another option is to give patients the standard smoking cessation treatment in addition to treatment for their PTSD symptoms (called prolonged exposure). However, it is not known which method works better. In order to answer this question, patients will be assigned by chance to one of two groups. One group will be given standard smoking cessation treatment to help quit smoking. A second group will be given the standard smoking cessation intervention to help quit smoking in addition to a form of psychotherapy called Prolonged Exposure to reduce symptoms of PTSD. The patients will be randomly assigned (by chance) to one of these groups. If the patient is assigned to the smoking cessation only condition and the patient still has PTSD symptoms after the last study visit (week 24) the patient will be offered treatment for your PTSD symptoms (Prolonged Exposure) at no cost. The patient’s participation will help the investigators determine if treating PTSD symptoms enhances the ability of standard smoking cessation to help people quit smoking. Participants will receive up to $200 in compensation by the completion of the study. 

Clinical Trials Registryhttp://clinicaltrials.gov/ct2/show/NCT01857739

Status: This study is currently recruiting participants.

IRB Protocol: 2013-06-0066

Learn more about treatment we use for PTSD: TED Talk About Prolonged Exposure Therapy

Please click here for more information on how to become involved.